49ers Star Battles Double Injury Setback—Can He Still Lead the Team?

So, here we are—San Francisco 49ers, fresh off a bruising Week 1 duel with the Seattle Seahawks, limping but still standing. You ever wonder if NFL players get a little thrill from the pain? Because judging by the lineup, these guys are taking hits like they’re on some twisted roller coaster ride. Wide receiver Jauan Jennings is nursing a shoulder injury, tight end George Kittle is sidelined with a hamstring that’s serious enough to send him to injured reserve, and the cherry on top? Brock Purdy—their franchise quarterback—is battling injuries that might bench him for the next game. It’s a real test of grit and depth, and honestly, it makes you wonder: can the Niners withstand the storm without their key players firing on all cylinders? With backup Mac Jones lurking, ready to step in if needed, this week’s showdown in New Orleans just got a whole lot more interesting. Buckle up, folks—this season might throw more curveballs than anyone expected.

The San Francisco 49ers survived a tough and gritty NFC West matchup with the Seattle Seahawks in Week 1.

However, they ended up banged up.

Wide receiver Jauan Jennings is dealing with a shoulder injury, and tight end George Kittle is heading to injured reserve after sustaining a hamstring injury.

If that wasn’t enough, quarterback Brock Purdy is dealing with multiple ailments and could miss their next game.

“Brock Purdy has a left shoulder and toe injury that make him uncertain for Sunday’s game in New Orleans. Kyle Shanahan said the team will see how the practice week goes. If Purdy cannot play, 49ers backup QB Mac Jones would be in line to start,” ESPN insider Adam Schefter wrote on X.

Brock Purdy has a left shoulder and toe injury that make him uncertain for Sunday’s game in New Orleans. Kyle Shanahan said the team will see how the practice week goes.

If Purdy cannot play, 49ers backup QB Mac Jones would be in line to start. pic.twitter.com/7ocnuD0UYI

— Adam Schefter (@AdamSchefter) September 8, 2025

The Niners have an experienced backup in Jones, but it would take a lot for the former New England Patriots QB to take Purdy’s job.

The Niners just spent a lot of money on a contract extension for Purdy, who had some ups and downs in the season opener, throwing for 277 yards with two touchdowns and two interceptions while completing 74.3 percent of his passes.

The New Orleans Saints looked more competitive than anticipated in their season-opening loss to the Arizona Cardinals, but they were at home against a team that might not be a contender.

Yet, the Niners can’t afford to overlook any opponent right now, and they will certainly hope that they will have their starting quarterback available.

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