2025 NFL Week 1 Odds Revealed: Which Underdog Could Shock the Season Opener?

Alright, folks, the 2025-26 NFL season has officially kicked off and what a whirlwind start it’s been! So far, the underdogs have taken center stage, flipping the script in both matchups we’ve witnessed. The Dallas Cowboys, despite being +8 underdogs, came oh-so-close but fell 24-20 to the Philadelphia Eagles. Meanwhile, the Los Angeles Chargers, also flying under the radar at +3, shocked everyone with a solid 27-21 victory over the Kansas City Chiefs—right there in Brazil, no less! It’s already shaping up to be a season full of surprises and plenty of edge-of-your-seat action. If you’re looking to dive deeper and get all the nitty-gritty details on the Week 1 action and the latest odds, I’ve got you covered. LEARN MORE

The 2025-26 NFL regular season has begun and both underdogs have covered in the two games played so far. The Dallas Cowboys (+8) lost 24-20 to the Philadelphia Eagles, while the Los Angeles Chargers (+3) beat the Kansas City Chiefs outright 27-21 in Brazil.

[Week 1 bets to make now | Helpful tips for new bettors]

Here are the odds for all the remaining Week 1 games at BetMGM:

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Sunday, Sept. 7

1 p.m. ET games

Arizona Cardinals (-6.5, 43) at New Orleans Saints

Cincinnati Bengals (-5.5, 47.5) at Cleveland Browns

Miami Dolphins at Indianapolis Colts (-1, 46.5)

Las Vegas Raiders at New England Patriots (-2.5, 42.5)

New York Giants at Washington Commanders (-6, 45.5)

Tampa Bay Buccaneers (-1, 47) at Atlanta Falcons

Carolina Panthers at Jacksonville Jaguars (-3.5, 47)

Pittsburgh Steelers (-3, 38) at New York Jets

4 p.m. ET games

Houston Texans at Los Angeles Rams (-3, 43.5)

San Francisco 49ers (-1, 43) at Seattle Seahawks

Tennessee Titans at Denver Broncos (-8.5, 42.5)

Detroit Lions at Green Bay Packers (-2, 47.5)

Sunday Night Football

Baltimore Ravens (-1, 50.5) at Buffalo Bills

Monday, Sept. 8

Minnesota Vikings (-1.5, 44) at Chicago Bears