Arizona Cardinals Face David vs. Goliath Battle Against Seahawks: Can Underdogs Defy the Odds Thursday?

Putting an 18-2 Thursday Night Football betting streak on the line always raises the stakes — but this week, Seahawks at Cardinals feels like a whole different beast. After Seattle’s dominant run following that close opener loss, and Arizona’s injury-laden struggles, the lines might just be tipping in one clear direction. Can Sam Darnold and his superstar WR Jaxon Smith-Njigba continue their pro-grade tear? Or will the depleted Cardinals defense, reeling without key corners, crumble under the pressure? Throw in last year’s double Seattle wins and Arizona’s rough schedule-adjusted offense, and you’ve got a recipe begging the question: is this the week the Seahawks roll, or will the Cardinals shock us despite the odds? I’m putting my Circa Million VII card where my mouth is — and hoping for no flashbacks to old Darnold. Wanna dive deeper into my take? LEARN MORE.

I’m putting my superb betting record for Thursday Night Football on the line in the Seattle Seahawks (2-1) at Arizona Cardinals (2-1) game in NFL Week 4. Since 2023, I’m 18-2 on sides and total bets on TNF, including 3-0 so far this season. Seahawks-Cardinals is different because, unlike the previous three weeks, I’m using my pick for Thursday on my Circa Million VII card for this week.

After losing the season opener to the San Francisco 49ers 17-13, Seattle breezed past the Pittsburgh Steelers 31-17 in Week 2 and stomped the New Orleans Saints 44-13 last week. Arizona’s first and only loss this season was also to the Niners last week, 16-15. Before that, the Cardinals beat New Orleans 20-13 in Week 1 and the Carolina Panthers 27-22 two weeks ago.

For what it’s worth, the Seahawks beat the Cardinals in both their meetings last season: 16-6 and 30-18. However, Seattle is better this season due to its continuity and upgrading from former QB Geno Smith to QB Sam Darnold this offseason. Moreover, Arizona should be getting at least +3 Thursday because it’s one of the most injured teams in the NFL currently.

Arizona got horrible injury news for this game Wednesday. Cardinals CBs Garrett Williams and Starling Thomas have already been ruled out, and second-round rookie CB Will Johnson is listed as “doubtful” for Thursday after not practicing all week. I can’t believe I’m typing this, but Seattle’s offense will move the ball based on Arizona’s injuries and how well Darnold is playing.

He is Pro Football Focus’s (PFF) highest graded quarterback through the first three weeks. Meanwhile, Darnold’s best weapon, WR Jaxon Smith-Njigba, looks like he’s going to be a superstar. JSN is PFF’s third-highest graded wide receiver so far this year, and last season, he broke out, catching 100 balls for 1,130 yards and six touchdowns.

Also, the Seahawks have two starters in their secondary, who didn’t play last week, returning Thursday: CB Devon Witherspoon and S Julian Love. The Cardinals lost RB James Conner to a season-ending injury Sunday and will be without starting WR Zay Jones this week. Until WR Marvin Harrison Jr. develops, if he ever does, Conner is Arizona’s best skill-position player.

Ultimately, the Seahawks shut down the Cardinals last year, and Arizona’s offense isn’t better this season. The Cardinals are only averaging 19.7 points per game, despite playing the easiest schedule in the NFL, per Inpredictable.com. Simply put, Kyler Murray doesn’t have enough weapons to score enough points on this defense. I’m just hoping we don’t see old Darnold Thursday.

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