49ers Drop Bombshell on Brock Purdy’s Future—What It Means for the Season

So here we are again, staring down the barrel of a Sunday showdown where the San Francisco 49ers, perched at a solid 4-1, are set to tangle with an equally impressive Tampa Bay Buccaneers squad. Now, if you’re wondering how the 49ers plan to navigate this gauntlet without their starting quarterback, Brock Purdy – sidelined once more by a toe injury – you’re not alone. It’s almost poetic, isn’t it? The guy looks on at Levi’s Stadium, the hopes of a city reflected in his gaze, while the team grapples with uncertainty. With Purdy out, Mac Jones steps back under center, carrying the weight of expectations and the question that looms large: Can he sustain his recent hot streak against Baker Mayfield’s explosive aerial assault? Meanwhile, San Francisco’s injury woes spread like wildfire, threatening to unravel their offensive tapestry. This isn’t just a game; it’s a high-stakes test of resilience, strategy, and maybe a little bit of luck. Buckle up — this one’s bound to keep us on the edge.

SANTA CLARA, CALIFORNIA - NOVEMBER 17: Brock Purdy #13 of the San Francisco 49ers looks on during warmups before a game against the Seattle Seahawks at Levi's Stadium on November 17, 2024 in Santa Clara, California. — (Photo by Lachlan Cunningham/Getty Images)

The 4-1 San Francisco 49ers head into Sunday’s matchup against the Tampa Bay Buccaneers facing a crucial test against another 4-1 team.

Tampa Bay brings one of the league’s most explosive passing attacks, led by quarterback Baker Mayfield, who has been playing at an elite level this season.

The challenge grows more complicated for San Francisco as starting quarterback Brock Purdy remains sidelined with a toe injury that has already cost him three games.

Initial optimism about Purdy’s potential return this weekend has diminished, leaving the 49ers in an uncertain position at the most critical spot on the field.

“49ers ruled out QB Brock Purdy and WR Ricky Pearsall for Sunday’s game at Tampa Bay. 49ers QB Mac Jones starts again,” ESPN’s Adam Schefter shared.

49ers ruled out QB Brock Purdy and WR Ricky Pearsall for Sunday’s game at Tampa Bay.

49ers QB Mac Jones starts again. pic.twitter.com/7FQglh7QKN

— Adam Schefter (@AdamSchefter) October 10, 2025

Jones has proven himself capable during this stretch, starting the season 3-0 while completing 66.7% of his passes for 905 yards, six touchdowns, and just one interception.

The 2021 first-round pick currently leads the team in both pass attempts and completions per game, displaying his sharpest form since his rookie campaign with the Patriots.

That 2021 season saw him complete 67.5% of throws for 3,801 yards, 22 touchdowns, and 13 interceptions across a full year.

The efficiency Jones has shown recently raises legitimate questions about his ability to maintain this production level against stronger opponents over an extended period.

This matchup against Mayfield’s high-powered passing game will provide a significant measuring stick for where Jones stands as a consistent starter.

San Francisco’s injury situation extends well beyond the quarterback position and could ultimately determine how they approach this game offensively.

Nick Bosa is done for the season following a torn ACL, while George Kittle will miss at least another game dealing with a hamstring issue.

Receivers Ricky Pearsall, Jauan Jennings, and Brandon Aiyuk have all missed time as well, creating real pressure across the offensive depth chart.

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