Astro-Nomical Clash: Expert Picks and Intriguing Odds as Astros Face Cardinals on April 16

The Houston Astros’ journey into St. Louis on a crisp Wednesday in April 2025 presents a tantalizing spectacle of baseball prowess at Busch Stadium. Both teams, sitting surprisingly even at 8-9, are in the throes of finding their rhythm in this early dance of the season. With the pristine field bathed in sunlight and shadows, anticipation builds as Ronel Blanco of Houston is set to face off against Steven Matz of St. Louis.

After last night’s shutout against the Cardinals, my heart still races thinking about how effectively Hunter Brown handled the game. That first shutout of the season was not just a win; it was a statement, a potential momentum propelling Houston to string together victories.

As we delve into the depths of this matchup, isn’t there something inherently thrilling about seeking that “sweat” — the nail-biting moments when games could swing either way? It’s not just about the odds; it’s about the stories unfolding with every pitch, strike, error, and ultimately, every confidence-drenched bet placed.

Now, let’s chew through the juicy stats, pitching insights, and predictions so you’re fully equipped for this midweek matchup.

Here we go, LEARN MORE: astros-cardinals-matchup-trends-and-betting-picks.

The latest odds as of Wednesday:
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!Top betting trends & insights to know ahead of Astros at Cardinals
Odds for the Astros at the CardinalsLast night was the first shutout for the Astros this season. They look to use that momentum to push a few wins together.Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.Expert picks & predictions for tonight’s game between the Astros and the Cardinals

Rotoworld Best BetProbable starting pitchers for Astros at Cardinals

• Date: Wednesday, April 16, 2025
• Time: 1:15PM EST
• Site: Busch Stadium
• City: St. Louis, MO
• Network/Streaming: FanDuel Sports Midwest, Space City Home Network

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Its Wednesday, April 16 and the Astros (8-9) are in St. Louis to take on the Cardinals (8-9). Game details & how to watch Astros at Cardinals

• Moneyline: Astros (-113), Cardinals (-106)
• Spread: Astros -1.5
• Total: 8.0 runs

The Astros beat the Cardinals last night 2-0, thanks to a run in the sixth and eighth innings. Hunter Brown was dealing. He picked up the win and pitched six shutout innings.

• Pitching matchup for April 16, 2025: Ronel Blanco vs. Steven Matz
  • Astros: Ronel Blanco, (1-1, 6.94 ERA)
    Last outing: 5.0 Innings Pitched, 2 Earned Runs Allowed, 5 Hits Allowed, 1 Walks, and 7 Strikeouts
  • Cardinals: Steven Matz, (0-0, 2.31 ERA)
    Last outing: 2.1 Innings Pitched, 1 Earned Runs Allowed, 5 Hits Allowed, 1 Walks, and 1 Strikeouts

Here are the best bets our model is projecting for Wednesday’s game between the Astros and the Cardinals:
Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

• The Astros have won 12 of their last 20 away games against teams with losing records
• In his last 5 starts on the mound the Cardinals pitcher Steven Matz has an ERA of 8.74
• The Cardinals have covered in 4 of their last 5 home games with Steven Matz as starting pitcher to return 3.78 units

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.Lets dive into the matchup and find a sweat or two.Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

• Moneyline: NBC Sports Bet is recommending a play on the Houston Astros on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the St. Louis Cardinals at +1.5.
• Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBCRonel Blanco is slated to take the mound for Houston against Steven Matz for St. Louis.

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