Can Philip Rivers Defy the Odds and Deliver a Holiday Upset for the Colts?
The 49ers love to run quick passing concepts out of shotgun, and many of those plays are designed to create space for McCaffrey.
He will have an interesting matchup in Week 16, however, as he faces an Indianapolis defense that has allowed just 364 receiving yards to running backs all season.
Colts vs. 49ers Prediction
This matchup is about as hard to predict as it gets, specifically on the Indianapolis sideline.
Most of the yearlong trends and statistics can be thrown out the window as the Colts try to rebuild their offense on the fly around a 44-year-old quarterback.
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