College Football Week 6: Unbelievable Upset Predictions That Could Shake the Season!
No. 31 SMU 42.1% at No. 19 Louisville 57.9%
Louisville has outscored its opponents by 102 points through its first four games, its highest point differential through four games since 2016 (plus-164). The Cardinals’ +102 point differential is 20 points higher than any other FBS team that was not undefeated through their first four games this season (Arkansas, +82).
No. 37 Iowa 7.2% at No. 3 Ohio State 92.8%
Ohio State has won eight straight home games against Iowa dating back to 1995, with the
Buckeyes winning by an average margin of 19.7 points over this streak. Each of Iowa’s last two overall wins against Ohio State (2017, 2004) have been won by 26+ points.


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