Colorado Football Coach Deion Sanders Reveals Urgent Health Battle Behind the Scenes

Deion Sanders, the charismatic face of Colorado football, is back in the headlines — but this time it’s not a jaw-dropping play or a fiery halftime speech making waves. Instead, Coach Prime is once again battling blood clots in his leg, a stubborn health challenge following his courageous fight with bladder cancer last offseason. Despite the Colorado Buffaloes’ rough 2-4 start and standings that have them knotted at the bottom of the Big 12, Sanders’ indomitable spirit shines brighter than ever. Undergoing a grueling four-hour procedure, he’s already geared up to return to the sidelines in a mere 24 hours — talk about grit and faith! It begs the question: in a season filled with tough breaks on and off the field, can Sanders’ relentless resolve be the spark that pulls the Buffaloes back from the brink? Well, if anyone can turn heartbreak into hustle, it’s the man known for making miracles happen under stadium lights. LEARN MORE.

Colorado football coach Deion Sanders recently revealed he is dealing with medical issues once again. Following a loss to TCU, Sanders told reporters he thought he had blood clots in his leg again. Now, Sanders is revealing more information about his medical issue.

Sanders is undergoing a four-hour procedure Tuesday to remove the blood clots from his leg, per On3. The Colorado coach is expected back on the field Wednesday, for team practice.

“I am having a procedure today,” Sanders said Tuesday, per Buffalo Stampede. “Prayerfully I’ll be right back at practice tomorrow. It is what it is. Found what we found. I have a wonderful team of doctors at UC Health and a team of wonderful trainers here. It has nothing to do with me working at the level and competing … it is hereditary. It is what it is. I trust God with all my heart.”

Sanders was treated for bladder cancer this past offseason. He is cleared of the cancer, but blood clots appear to be hampering him once again.

Colorado football is 2-4 on the season.

Colorado football has had a frustrating season

Colorado Buffaloes mascot Ralphie the Buffalo runs on the field before the game against the Brigham Young Cougars at Alamodome. — Troy Taormina-Imagn Images

Colorado is tied for last in the Big 12 conference standings this season. The Buffaloes are 0-3 in conference play. The team’s only victories this year are over Wyoming and Delaware.

The squad has had to replace a lot of talent, who left after the 2024 season. That includes two of Coach Sanders’ sons, in Shedeur and Shilo. Heisman Trophy winner Travis Hunter is also gone, and doing amazing things in the NFL with the Jacksonville Jaguars.

It has been difficult for Colorado to replace them. The team is dangerously close to their second losing season in just three years under Sanders. Sanders has helped guide Colorado in their transition from the Pac-12 conference to the Big 12.

With the Sanders brothers and Hunter, Colorado football posted a nine win season in 2024. It was one of the best years in the history of the program. Buffaloes fans had hoped for continued success in the 2025 campaign.

Colorado next plays Iowa State on Saturday. Iowa State is trying to recover from a disappointing defeat at the hands of Cincinnati.

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