Guardians vs. Diamondbacks: Expert Predictions Reveal Surprising Betting Trends and Key Starting Pitchers for August 19 Clash

The Cleveland Guardians, sitting comfortably at 64-60, are making their way to Phoenix for a key showdown against the Diamondbacks, who hold a slightly shakier 60-66 record. Mark your calendars for Tuesday, August 19 — Tanner Bibee will toe the rubber for Cleveland, squaring off against Arizona’s Eduardo Rodriguez. After snapping a three-game skid with a tight 4-3 victory over the D-backs in the opener, the Guardians look to build on that momentum. Meanwhile, the Diamondbacks are trudging through a rough patch, having lost four straight games by a total of seven runs.

This contest could be a real nail-biter, and I’m itching to break down all the nitty-gritty: pitching matchups, recent team form, player insights, and of course, the best bets our experts and models are pointing towards. Oh, and if fantasy stats and betting news are your jam, Rotoworld has you covered all season long.

Keep reading if you want the full scoop on how to catch the first pitch, streaming info, odds, and the inside track on who’s got the edge come game time. It’s shaping up to be quite the battle under the desert lights, and you won’t want to miss a moment. LEARN MORE

It’s Tuesday, August 19 and the Guardians (64-60) are in Phoenix to take on the Diamondbacks (60-66). Tanner Bibee is slated to take the mound for Cleveland against Eduardo Rodriguez for Arizona.

The Guardians won the series opener, 4-3, over the DBacks, to break a three-game losing streak. For Arizona, the Diamondbacks are on a four-game losing skid after dropping all four by seven combined runs.

Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

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Game details & how to watch Guardians at Diamondbacks

• Date: Tuesday, August 19, 2025
• Time: 9:40PM EST
• Site: Chase Field
• City: Phoenix, AZ
• Network/Streaming: CLEG, ARID, MLBN

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Guardians at the Diamondbacks

The latest odds as of Tuesday:

• Moneyline: Guardians (-105), Diamondbacks (-115)
• Spread: Diamondbacks 1.5
• Total: 9.0 runs

Probable starting pitchers for Guardians at Diamondbacks

• Pitching matchup for August 19, 2025: Tanner Bibee vs. Eduardo Rodriguez
  • Guardians: Tanner Bibee, (9-9, 4.54 ERA)
    Last outing: 3.18 ERA, 2 Earned Runs Allowed, 5 Hits Allowed, 4 Walks, and 5 Strikeouts
  • Diamondbacks: Eduardo Rodriguez, (5-7, 5.40 ERA)
    Last outing: 1.29 ERA, 1 Earned Runs Allowed, 6 Hits Allowed, 1 Walks, and 6 Strikeouts

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Expert picks & predictions for tonight’s game between the Guardians and the Diamondbacks

Rotoworld Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Tuesday’s game between the Guardians and the Diamondbacks:

• Moneyline: NBC Sports Bet is recommending a play on the Arizona Diamondbacks on the Moneyline.
• Spread: NBC Sports Bet is leaning towards a play ATS on the Cleveland Guardians at +1.5.
• Total: NBC Sports Bet is staying away from a play on the Game Total of 9.0.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.

Top betting trends & insights to know ahead of Guardians at Diamondbacks

• Cleveland is 1-3 in the last 4 games
• Arizona is 0-4 in the last 4 games
• Arizona is 3-4 in the past 7 games
• The Guardians have lost their last 3 games following a win
• The Under is 4-1 in the Diamondbacks’ last 5 games
• The Diamondbacks have failed to cover the Run Line in 4 straight games

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

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• Jay Croucher (@croucherJD)
• Drew Dinsick (@whale_capper)
• Vaughn Dalzell (@VmoneySports)
• Trysta Krick (@Trysta_Krick)