Unexpected Shifts in NFL Week 3 Betting Odds: Which Underdog Could Upset the Titans?

Still two Monday Night Football games left on the board in Week 2, yet sportsbooks are already sprinting ahead with Week 3 odds—and honestly, can you blame them? The NFL waits for no one, especially when there’s a juicy rematch brewing between the Los Angeles Rams and the reigning Super Bowl champs, the Philadelphia Eagles. I mean, how often do you get a gnarly divisional showdown before the calendar even flips? It’s like the league’s tossing us a spicy appetizer while we’re still finishing our main course. DraftKings didn’t waste a second, dropping moneylines, spreads, and totals for all 16 games as of late Sunday night, September 14—talk about eagerness! Sure, some Week 2 matchups are still on tap, but hey, why not get a jump start on those bets? If you’re like me, always hunting that edge, this early intel is pure gold — serving up more questions than answers: Which teams are truly ready to take flight, and who’s just winging it? Grab your betting slip—it’s about to get interesting. LEARN MORE.

There are still two Monday Night Football games to play in NFL Week 2, but sportsbooks wasted no time releasing the odds for next week’s slate. Check out DraftKings’ first-look moneylines, spreads, and totals for all 16 games in Week 3, highlighted by a rematch from the 2025 NFC Divisional Round between the Los Angeles Rams and reigning Super Bowl champion Philadelphia Eagles. 

The odds are courtesy of DraftKings as of 11:20 p.m. ET Sunday, September 14. 

*The Raiders still need to play the Los Angeles Chargers on Monday Night Football in NFL Week 2. 

**Tampa Bay still needs to play the Houston Texans on Monday Night Football in NFL Week 2. 

***The Texans have to play the Buccaneers on Monday Night Football in NFL Week 2 still. 

****The Chargers still have to play the Raiders on Monday Night Football in NFL Week 2. 

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