Unlock Thursday’s MLS Secrets: Can You Crack the 5/1 Winning Code?

The midweek stage is set for some high-stakes drama under the bright lights of MLS, with Thursday’s early kickoff brimming with intrigue. Inter Miami, a team many pegged to crush the Eastern Conference, finds itself clawing for momentum amid a rough patch that’s left fans and pundits scratching their heads. Meanwhile, Vancouver continues to soar, eager to widen the gap atop the Western Conference standings. If you’re contemplating throwing down a bet or just craving a sneak peek into what the week holds, you’ll want to zero in on our specially curated MLS betting tips. Trust me, the matchups and scenarios brewing here are too good to miss. LEARN MORE

With America’s elite stealing plenty of the midweek headlines, we have a stacked MLS schedule on the cards from across the early hours of Thursday.

As the likes of Inter Miami desperately seeking an essential boost, a high-flying Vancouver will also look to extend their buffer at the top of the Western Conference standings.

For those of you looking to stick on a midweek flutter, we have taken a look at some of the most appealing MLS betting tips.

00:30 Inter Miami vs CF Montreal 

While Inter Miami might have opened up the 2025 pencilled in as a landslide contender to defend their Eastern Conference crown, the Herons are desperately seeking a recent boost. Opening the midweek fixtures holding just a single point buffer from slipping out of the top-seven, Javier Mascherano’s men have remarkably mustered just a sole win from any of their previous eight appearances across all competitions. With a 4-1 victory against the New York Red Bulls their only win since April 19th, the one-time Liverpool midfielder will also have a major headache over his side’s glaring defensive struggles. Despite mounting a last-gasp comeback away at Philadelphia last week as they played out a thrilling 3-3 stalemate, Inter Miami have shipped a staggering 13 goals in just their previous four MLS outings. It should also be highlighted, the Herons have failed to muster a single clean sheet in front of their own supporters since the start of March.

Enduring what has become a public MLS nightmare this season, Montreal have rightfully come under a huge amount of scrutiny since opening up the 2025 campaign. Suffering a collapse on home soil last week as they eventually had to settle for a 2-2 stalemate at home against Los Angeles, interim boss Marco Donadel has a huge job on his hands. Putting in a woeful display on May 17th as they slumped to a 6-1 drumming at the hands of bitter rivals Toronto, Thursday’s guests have remarkably put just eight points on the board from any of their 15 MLS appearances so far this season. Sat rock-bottom of the Eastern Conference standings, Montreal should also be concerned by their most recent showdown against Inter Miami. Hit with an action-packed 3-2 loss when they welcomed the MLS giants to town last season, the Impact are pencilled in as a landslide underdog here.

Inter Miami vs CF Montreal Betting Tip: Inter Miami win & Both teams to score @ 7/4 with Pribet

03:30 Portland Timbers vs Colorado Rapids 

Suffering what has become a frustrated run over the past few weeks, Portland are looking to claim a welcomed boost here. Nevertheless, making a string of improvements since opening up the 2025 campaign, Phil Neville’s men will be excited to make a return to Providence Park in the early hours of Thursday. Getting the midweek fixtures underway sat firmly in the driving seat to book a top-seven finish in the Western Conference, Portland are unbeaten in all of their previous six showdowns in Oregon. Likewise, the former Inter Miami boss has seen his squad suffer just a single defeat from any of their first 10 matchups in front of their own supporters so far this year. Knowing that they could leap up into bronze medal position, it should also be highlighted, Neville’s side stormed their way to a stellar 4-0 romp when they welcomed the Rapids to Oregon last season.

Clinching consecutive 1-0 victories against Real Salt Lake and St. Louis City over the past fortnight, Colorado are enjoying their most fruitful spell since the middle of March. However, last seen on their travels getting hit with a routine 2-0 defeat against San Diego, Thursday’s guests have gained a reputation for their glaring issues away from Dick’s Sporting Goods Park. Getting May underway with a 2-1 loss at the hands of DC United, Chris Armas’ side have registered just a single point from their last four MLS showdowns outside of Denver. Likewise, slumping to that 4-0 defeat when they travelled to Portland last season, the Rapids do hold a worrying record against the midweek hosts. Along with losing four of their previous five meetings, Colorado have also claimed just a sole victory from their last seven battles – a run that stems back to May 2022.

Portland Timbers vs Colorado Rapids Betting Tip: Portland Timbers win & Under 4.5 goals @ 5/4 with Luckster

Thursday’s MLS Double

• Inter Miami vs CF Montreal – Inter Miami win & Both teams to score @ 7/4
• Portland Timbers vs Colorado Rapids – Portland Timbers win & Under 4.5 goals @ 5/4

Place a £10 bet on our Daily Double with Vegas Land and pocket £61.88 if all predictions are correct.

You can also visit our betting promotions section for the latest enhanced odds promos, accumulator bonuses and more.