Week 2 NFL Injury Report: Shocking Updates That Could Make or Break Your Fantasy Football Season

Week 1 of the 2025 NFL season is officially in the books, and if you’re anything like me, you’ve been on edge watching your fantasy roster dodge major pitfalls. Although the injury bug hasn’t gone wild just yet, a handful of key players have already been sidelined or are teetering on the brink, forcing us to rethink our strategies as we dive headfirst into Week 2. It’s never just about the names on the field — it’s about who’s off it, and those absences can shake up games and fantasy lineups alike in a heartbeat. So, buckle up. We’re breaking down all the injury updates from Week 1 and keeping tabs on fresh names emerging on the reports as the week unfolds. Get ready to pivot, adjust, and finally crush that waiver-wire game. LEARN MORE

We’ve nearly made it through the first week of the 2025 NFL season and, hopefully, your fantasy football squads remain relatively unscathed. Week 1 hasn’t featured a ton of injuries, but a handful of them are impactful and ones we’ll need to keep a close eye on heading into the second week of the season.

Below, we’ll be tracking players who were injured during Week 1 and new names that pop up on injury reports throughout the week.

Week 1 injury recap

Brock Bowers, TE, Raiders (knee) — Bowers was forced to leave Week 1 with a knee injury and didn’t return in the second half. After the game, Bowers told reporters he’s “fine” and it doesn’t seem like anything serious. Still, Bowers is a very important player and we’ll see if he pops up on an injury report during the week. Luckily, the Raiders play the Chargers on MNF in Week 2. Michael Mayer becomes very relevant in fantasy if Bowers were to miss any time.

George Kittle, TE, 49ers (hamstring) — The 49ers placed Kittle on injured reserve on Tuesday due to his hamstring injury sustained in Week 1 vs. the Seahawks. That means Kittle will be out for at least the next four weeks. Initial reports stated that Kittle was expected to miss anywhere from 3-5 weeks. The earliest Kittle can return appears to be Week 6 when the Niners are on the road against the Bucs on Oct. 12. With Kittle sidelined, expect Kyle Shanahan to lean heavily on the run game with Christian McCaffrey and Brian Robinson Jr. Backup TE Jake Tongus got some run while Kittle was out in Week 1. He could turn out to be a decent waiver-wire option in deeper formats if you’re desperate at TE.

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Jauan Jennings, WR, 49ers (shoulder) — The Niners took another hit late in their game at Seattle with Jennings exiting due to a shoulder issue. The FOX broadcast said Jennings could “barely lift his arm” after the injury. Jennings entered Week 1 dealing with a calf injury that held him out during camp and preseason. If Jennings were to miss time, Ricky Pearsall becomes the default No. 1 WR and possibly the top receiving option for Brock Purdy outside CMC (if Kittle is also out). Pearsall finished Week 1 with four catches on seven targets for 108 yards. After more tests early in the week, Jennings is being considered day-to-day and has a chance to play Sunday vs. the Saints, per ESPN’s Adam Schefter.

Drake London, WR, Falcons (shoulder) — London wasn’t able to finish Week 1’s loss to the Bucs due to a shoulder injury. Reports are saying that London suffered a shoulder sprain and is considered day-to-day, but he’s expected to play in Week 2. London finished Week 1 with eight catches on 15 targets for 55 yards. Atlanta was also missing Darnell Mooney against the Bucs. Both receivers practiced on Wednesday, a good sign for their Week 2 availability.

Puka Nacua, WR, Rams (head) — Nacua exited after what appeared to be a big helmet-on-helmet hit. He was evaluated for a concussion but was able to return before exiting again, and subsequently returned. Nacua was able to finish the game with 10 catches on 11 targets for 130 yards. It seems he’s OK for now but worth monitoring this week during practice.

Xavier Worthy, WR, Chiefs (shoulder) — Worthy suffered a dislocated shoulder on Friday in the Chiefs’ opening loss to the Chargers, and the team and player will be electing rehab instead of surgery for the ailment. We don’t have an exact timetable for a return for Worthy, but it’s safe to say he won’t be in there for Week 2, though the Chiefs have labeled him day-to-day. He didn’t practice on Wednesday, likely the first sign of his absence in Week 2. The Chiefs will not be placing Worthy on IR at this time.

With Worthy and Rashee Rice (suspension) out and rookie Jalen Royals missing practice again, the Chiefs should continue to lean on TE Travis Kelce along with WRs Hollywood Brown (16 targets in Week 1), JuJu Smith-Schuster and Tyquan Thornton.

Evan Engram, TE, Broncos (calf) — Engram was forced to exit in Denver’s win over the Titans in Week 1. He finished the contest with three catches on four targets for 21 yards. The Broncos used all three of their tight ends on Sunday and a number of different receivers. Adam Trautman would take over as the de factor No. 1 TE if Engram were to miss time. Though, Trautman wouldn’t have much fantasy upside and is only really a consideration in deeper formats if Engram misses time.

Dallas Goedert, TE, Eagles (knee) — Goedert came up on Wednesday’s injury report with a sprained knee. His status is up in the air for Week 2, but the injury isn’t expected to sideline him long-term.