Week 6 NFL Betting Odds Revealed: Can the Underdogs Shock on SNF and MNF?

NFL Week 6 is shaping up to be a fascinating minefield packed with sneaky trap lines, teams masquerading as contenders, and a handful stubbornly clinging to relevance like it’s their last lifeline. Philadelphia Eagles and New York Giants set the stage Thursday night — but wait, there’s more: a London game back-to-back, plus not one, but two Monday Night Football matchups making a comeback. With all these storylines swirling, one has to ask—who’s really got teeth in this season, and who’s just playing pretend? Let’s dive headfirst into the initial moneylines, spreads, and totals to separate the wheat from the chaff. Odds fresh from DraftKings as of 12:15 a.m. ET Monday, October 6. LEARN MORE.

NFL Week 6 is loaded with trap lines, fake contenders, and a few teams still pretending they matter. The Philadelphia Eagles and the New York Giants kick things off Thursday night. There’s a London game for a second straight week, and we’re back to two Monday Night Football games. Let’s get into the first-look moneylines, spreads, and totals for this week.

The odds are courtesy of DraftKings as of 12:15 a.m. ET Monday, October 6.

*Jacksonville still needs to play the Kansas City Chiefs on Monday Night Football in NFL Week 5.

Kansas City still needs to play Jacksonville on Monday Night Football in NFL Week 5.

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