Week 16 NFL Showdowns: Surprising Picks and Shocking Probabilities You Can’t Afford to Miss!
Monday Night Football Prediction
San Francisco 49ers (10-4) at Indianapolis Colts (8-6)
- Opta Supercomputer’s Win Probability: Colts 50.3%
- Playoff Probabilities: 49ers 97.3%/Colts 11.2%
- All-Time Regular Season Meetings: Colts 27-18
- Last Meeting: Colts 30, 49ers 18 (Oct. 24, 2021)
Quick Hit: The Colts have won five straight against the 49ers, one behind their longest active streak against a single team. It is the Colts’ second-longest winning streak in matchup history behind a 13-game run from 1962-68 when the teams were in the same division.
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